Western New York Veteran Affairs Healthcare System, Buffalo, NY, USA.
Sleep Breath. 2011 Sep;15(3):393-401. doi: 10.1007/s11325-010-0346-3. Epub 2010 May 12.
Patients with obstructive sleep apnea (OSA) have an increased risk of perioperative complications.
The purpose of this study is to assess whether OSA increases the risk of cardiorespiratory complications in patients undergoing endoscopic procedures.
A retrospective study was performed. We identified all patients who had undergone both an endoscopic procedure under conscious sedation and a sleep study from January 2001 to May 2008. Patients were divided into four groups: OSA negative (apnea-hypopnea index (AHI) < 5/h), OSA positive; mild: AHI 5-15/h, moderate: AHI 15.1-30/h, and severe: AHI > 30/h. Minor and major complications were identified. The minor ones were hypertension, hypotension, bradycardia, tachycardia, oxygen desaturation (<90%), and bradypnea. Major complications included chest pain, respiratory distress, cardiorespiratory arrest, or any minor complication that required intervention.
Procedures were performed in 639 patients: colonoscopies 68.5%, upper endoscopies 20.2%, and combined procedures 11.3%. The mean age was 60.5 years, mean body mass index 33.7, and 93% were males. Sleep study results: 130 negative, 509 positive; 135 mild, 125 moderate, and 249 severe. Of the patients, 19% had minor complications, while 7% had major complications. There was no significant difference between the patients with and without OSA in the rate of minor complications (odds ratio 1.17, 95% confidence interval 0.70-1.92) or major complications (odds ratio 1.19, 95% confidence interval 0.54-2.63). The odds ratio was also not significantly increased when a cutoff value of 10 or 15/h was used to delineate a positive sleep study.
For patients undergoing endoscopy procedures under conscious sedation, the presence of OSA does not clearly increase the risk of cardiorespiratory complications.
阻塞性睡眠呼吸暂停(OSA)患者围手术期并发症的风险增加。
本研究旨在评估 OSA 是否会增加接受内镜检查患者发生心肺并发症的风险。
进行了一项回顾性研究。我们确定了所有在 2001 年 1 月至 2008 年 5 月期间同时接受过内镜检查和睡眠研究的患者。患者被分为四组:OSA 阴性(呼吸暂停低通气指数(AHI)<5/h)、OSA 阳性;轻度:AHI 5-15/h、中度:AHI 15.1-30/h 和重度:AHI>30/h。确定了轻微和主要并发症。轻微并发症包括高血压、低血压、心动过缓、心动过速、氧饱和度下降(<90%)和呼吸过缓。主要并发症包括胸痛、呼吸困难、心肺骤停或任何需要干预的轻微并发症。
共对 639 例患者进行了检查:结肠镜检查 68.5%、上消化道内镜检查 20.2%、联合检查 11.3%。患者平均年龄为 60.5 岁,平均体重指数为 33.7,93%为男性。睡眠研究结果:130 例阴性,509 例阳性;135 例轻度,125 例中度,249 例重度。患者中有 19%出现轻微并发症,7%出现严重并发症。有 OSA 与无 OSA 的患者在轻微并发症(比值比 1.17,95%置信区间 0.70-1.92)或严重并发症(比值比 1.19,95%置信区间 0.54-2.63)发生率方面无显著差异。当使用 10 或 15/h 作为截断值来划定阳性睡眠研究时,比值比也没有显著增加。
对于接受镇静内镜检查的患者,OSA 的存在并不能明显增加心肺并发症的风险。