Agarwal Anil, Arora Anil, Kumar Sudhir
Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi.
Indian J Tuberc. 2009 Oct;56(4):201-5.
This study examines the perspective of senior orthopaedic faculty and infectious disease experts from the Indian subcontinent and other countries on the appropriate duration of multi drug antitubercular chemotherapy in osteoarticular tuberculosis.
A questionnaire regarding what antitubercular drugs, their dosage and for how long was asked to attending faculty in an International Conference on musculoskeletal infections.
Thirty different prescriptions were obtained from a total of 52 respondents. Forty-two respondents voted against short course (6 months) regimen. The mode value for duration of treatment with isoniazid and rifampicin treatment in the study was 12 months; for pyrazinamide, it was three months. There was almost no consensus over the duration of treatment with ethambutol.
There is a strong need to assess long-term impact of DOTS in osteoarticular tuberculosis to facilitate the National Tuberculosis Programme planning, uniform training, wider acceptance, drug ordering and distribution. An effective communication between those planning national tuberculosis programmes and experts in osteoarticular tuberculosis is essential for universal acceptance of the management protocols.
本研究调查了来自印度次大陆及其他国家的资深骨科教员和传染病专家对骨与关节结核多药抗结核化疗合适疗程的看法。
在一次肌肉骨骼感染国际会议上,向与会教员发放了一份关于抗结核药物、剂量及疗程的问卷。
共52名受访者提供了30种不同的处方。42名受访者反对短程(6个月)治疗方案。本研究中异烟肼和利福平治疗疗程的众数为12个月;吡嗪酰胺为3个月。对于乙胺丁醇的疗程几乎没有达成共识。
迫切需要评估直接观察短程治疗(DOTS)对骨与关节结核的长期影响,以促进国家结核病规划、统一培训、更广泛接受、药物订购和分发。国家结核病规划制定者与骨与关节结核专家之间的有效沟通对于管理方案的普遍接受至关重要。