失去的增强子的记忆。
Memories of lost enhancers.
机构信息
Laboratory of Cellular and Molecular Biology, National Institute of Aging, Baltimore, Maryland 21224, USA.
出版信息
Genes Dev. 2010 May 15;24(10):973-9. doi: 10.1101/gad.1930610.
Abstract
Transcriptional enhancers are key determinants of developmentally regulated gene expression. Models of enhancer function must distinguish between analog or digital control of transcription, as well as their requirement to initiate or maintain transcriptional activity of a gene. In light of a recent study by Chong and colleagues (pp. 659-669) providing evidence of a transient requirement of an enhancer associated with the CD4 gene, we discuss possible mechanisms by which transcriptional memory can be propagated in the absence of enhancers.
摘要
转录增强子是发育调控基因表达的关键决定因素。增强子功能的模型必须区分转录的模拟或数字控制，以及它们启动或维持基因转录活性的要求。鉴于 Chong 及其同事最近的一项研究（第 659-669 页）提供了与 CD4 基因相关的增强子存在短暂需求的证据，我们讨论了在没有增强子的情况下如何传播转录记忆的可能机制。
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