Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Curr Opin Plant Biol. 2010 Aug;13(4):472-7. doi: 10.1016/j.pbi.2010.04.007. Epub 2010 May 17.
In plants, many of the innate immune receptors or disease resistance (R) proteins contain a NB-LRR (Nucleotide-binding site, Leucine-rich repeat) structure. The recent findings regarding NB-LRR signaling are summarized in this article. An emerging theme is that two NB-LRRs can function together to mediate disease resistance against pathogen isolates. Also, recent results delineate the NB-LRR protein fragments that are sufficient to initiate defense signaling. Importantly, distinct fragments of different NB-LRRs are sufficient for function. Finally, we describe the new roles of accessory proteins and downstream host genes in NB-LRR signaling.
在植物中,许多先天免疫受体或疾病抗性(R)蛋白含有 NB-LRR(核苷酸结合位点,富含亮氨酸重复)结构。本文总结了最近关于 NB-LRR 信号的发现。一个新兴的主题是,两个 NB-LRR 可以共同作用,介导对病原体分离株的抗性。此外,最近的结果描绘了足以启动防御信号的 NB-LRR 蛋白片段。重要的是,不同 NB-LRR 的不同片段足以发挥功能。最后,我们描述了辅助蛋白和下游宿主基因在 NB-LRR 信号中的新作用。