Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J Nucl Med. 2010 Jun;51(6):862-5. doi: 10.2967/jnumed.110.076471. Epub 2010 May 19.
The aim of this study was to examine the prevalence, distribution, and topographic relationship of vascular (18)F-sodium fluoride uptake and arterial calcification in major arteries.
Image data obtained from 75 patients undergoing whole-body (18)F-sodium fluoride PET/CT were evaluated retrospectively. Arterial radiotracer uptake and calcification were analyzed qualitatively and semiquantitatively.
(18)F-sodium fluoride uptake was observed at 254 sites in 57 (76%) of the 75 study patients, and calcification was observed at 1,930 sites in 63 (84%) of the patients. Colocalization of radiotracer accumulation and calcification could be observed in 223 areas of uptake (88%). However, only 12% of all arterial calcification sites showed increased radiotracer uptake.
Our data indicate the feasibility of (18)F-sodium fluoride PET/CT for the imaging of mineral deposition in arterial wall alterations. (18)F-sodium fluoride PET/CT may provide relevant information about the morphologic and functional properties of calcified plaque.
本研究旨在探讨血管摄取氟[18]化钠（18F-sodium fluoride）和大血管钙化的分布和分布关系。
回顾性分析了 75 例行全身氟[18]化钠（18F-sodium fluoride）正电子发射断层扫描/计算机断层扫描（PET/CT）的患者的图像数据。对动脉示踪剂摄取和钙化进行了定性和半定量分析。
75 例研究患者中，57 例（76%）有 254 个部位观察到氟[18]化钠摄取，63 例（84%）有 1930 个部位观察到钙化。摄取部位有 223 处（88%）可见示踪剂积聚和钙化的重合。然而，只有 12%的所有动脉钙化部位显示出摄取增加。
我们的数据表明氟[18]化钠 PET/CT 对动脉壁改变中矿物质沉积的成像具有可行性。氟[18]化钠 PET/CT 可能为钙化斑块的形态和功能特性提供相关信息。
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