Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Antimicrob Agents Chemother. 2010 Aug;54(8):3516-9. doi: 10.1128/AAC.01756-09. Epub 2010 May 24.
Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the human antimicrobial peptide LL-37 induces the mefE promoter and confers resistance to erythromycin and LL-37. Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease.
大环内酯类耐药性是肺炎链球菌治疗的主要关注点。这种肺炎链球菌的诱导性大环内酯类耐药性是由外排泵 MefE/Mel 介导的。我们在这里表明,人类抗菌肽 LL-37 可诱导 mefE 启动子,并赋予对红霉素和 LL-37 的耐药性。这种诱导可能会影响宿主防御和基于大环内酯类药物治疗肺炎球菌病的疗效。