New York-Presbyterian Hospital, New York, New York, USA.
Emerg Infect Dis. 2010 Jun;16(6):971-3. doi: 10.3201/eid1606.100165.
We report 2 patients with invasive aspergillosis after infection with pandemic (H1N1) 2009. Influenza viruses are known to cause immunologic defects and impair ciliary clearance. These defects, combined with high-dose corticosteroids prescribed during influenza-associated adult respiratory distress syndrome, may be novel risk factors predisposing otherwise immunocompetent patients to invasive aspergillosis.
我们报告了 2 例感染大流行(H1N1)2009 流感病毒后继发侵袭性曲霉菌病的患者。众所周知,流感病毒可导致免疫缺陷并损害纤毛清除功能。这些缺陷,再加上流感相关性成人呼吸窘迫综合征期间使用的大剂量皮质类固醇,可能是使原本免疫功能正常的患者易患侵袭性曲霉菌病的新的危险因素。