Department of Rheumatology & Immunology Duke University Health System, Durham, UK.
Best Pract Res Clin Rheumatol. 2010 Jun;24(3):373-85. doi: 10.1016/j.berh.2009.12.004.
Most pregnancies in women with rheumatologic disease will result in the delivery of a healthy baby. Pregnancy can be particularly risky in women with active disease or on teratogenic medications, making contraception an important issue for these women. All women with rheumatologic disease have contraceptive options, including barrier methods, the intra-uterine device and progesterone-only medications. Active inflammatory disease, whether in the form of lupus, systemic vasculitis or myositis, places the pregnancy at increased risk. Pre-eclampsia is a particular risk for women with lupus or antiphospholipid syndrome and may be decreased by daily low-dose aspirin. Rheumatoid arthritis typically improves and does not have a major impact on pregnancy outcomes. The expected post-partum arthritis flare may be avoided by restarting medications soon after delivery. Judicious use of medication and close observation may be the keys to successful pregnancy in women with rheumatologic disease.
大多数患有风湿性疾病的女性的妊娠都会生下健康的婴儿。患有活动期疾病或使用致畸药物的女性妊娠风险特别高，因此避孕对这些女性来说是一个重要问题。所有患有风湿性疾病的女性都有避孕选择，包括屏障方法、宫内节育器和孕激素仅药物。无论是狼疮、系统性血管炎还是肌炎形式的活动性炎症，都会使妊娠风险增加。子痫前期是狼疮或抗磷脂综合征女性的一个特殊风险，每天低剂量阿司匹林可降低其风险。类风湿关节炎通常会改善，并且对妊娠结局没有重大影响。通过在分娩后不久重新开始用药，可以避免预期的产后关节炎发作。在患有风湿性疾病的女性中，谨慎使用药物和密切观察可能是成功妊娠的关键。
