五味子属果实中的三萜内酯。

Nortriterpene lactones from the fruits of Schisandra arisanensis.

机构信息

School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road Sec. 1, Taipei 100, Taiwan, Republic of China.

出版信息

J Nat Prod. 2010 Jul 23;73(7):1228-33. doi: 10.1021/np100048h.

DOI:10.1021/np100048h

PMID:20536188

Abstract

Fractionation of an acetone extract from the fruits of Schisandra arisanensis afforded five new nortriterpene lactones, compounds 1-5, together with four known compounds, schindilactones D and E (6 and 7) and preschisanartanins A and B (8 and 9). Compound 1, a wuweiziartane-type nortriterpenoid, possesses a new type of fused ring system with a gamma-lactone ring between C-15 and C-17. Compounds 2, 6, and 7 may be categorized as schisanartane-type nortriterpenoids and compounds 3-5, 8, and 9 as preschisanartane-type nortriterpenoids. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data interpretation. The structure and relative configuration of 3 were supported by single-crystal X-ray diffraction analysis. The antiviral activity against HSV-1 and inhibitory effects on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB of compounds 1-9 were evaluated.

摘要

从华中五味子果实的丙酮提取物中分离得到五个新的倍半萜内酯化合物 1-5，以及四个已知化合物，schindilactones D 和 E（6 和 7）和 preschisanartanins A 和 B（8 和 9）。化合物 1 是一种五味子烷型倍半萜，具有一种新的环系统，在 C-15 和 C-17 之间有一个γ-内酯环。化合物 2、6 和 7 可归类为 schisanartane 型倍半萜，化合物 3-5、8 和 9 为 preschisanartane 型倍半萜。新化合物的结构通过 1D 和 2D NMR 光谱数据解释来阐明。3 的结构和相对构型通过单晶 X 射线衍射分析得到支持。评估了化合物 1-9 对 HSV-1 的抗病毒活性以及对 FMLP/CB 诱导的人嗜中性粒细胞中超氧阴离子生成和弹性蛋白酶释放的抑制作用。