5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的ω-二烷基氨基烷基醚，具有抗血小板聚集及其他活性。

omega-Dialkylaminoalkyl ethers of 5-(arylmethylene)-1,3,3-trimethyl-2- oxabicyclo[2.2.2]octan-6-hydroxyimines with platelet antiaggregating and other activities.

作者信息

Mariani E, Bargagna A, Longobardi M, Schenone P, Losasso C, Donnoli D, Carnevale M, Marmo E

机构信息

Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.

出版信息

Farmaco. 1991 Jan;46(1):85-98.

Abstract

The synthesis of omega-dialkylaminoalkyl ethers 3 by the reaction of some 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6- hydroxyimines as sodium salts with the appropriate omega-chloroalkyldialkylamine in DMF solution is described. Some aminoethers 3 showed strong platelet antiaggregating activity in vitro superior to that of acetylsalicylic acid, as well as weak antiarrhythmic activity in rats and moderate infiltration anesthesia in mice.

摘要

描述了通过一些5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的钠盐与合适的ω-氯烷基二烷基胺在DMF溶液中反应合成ω-二烷基氨基烷基醚3的方法。一些氨基醚3在体外表现出强于乙酰水杨酸的血小板抗聚集活性，以及在大鼠中的弱抗心律失常活性和在小鼠中的中度浸润麻醉作用。

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omega-Dialkylaminoalkyl ethers of 5-(arylmethylene)-1,3,3-trimethyl-2- oxabicyclo[2.2.2]octan-6-hydroxyimines with platelet antiaggregating and other activities.5-（芳基亚甲基）-1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷-6-羟基亚胺的ω-二烷基氨基烷基醚，具有抗血小板聚集及其他活性。

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