猪 2 型圆环病毒相关呼吸道病猪肺中促炎细胞因子的表达。
Proinflammatory cytokine expression in the lung of pigs with porcine circovirus type 2-associated respiratory disease.
机构信息
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, Republic of Korea.
出版信息
Res Vet Sci. 2011 Apr;90(2):321-3. doi: 10.1016/j.rvsc.2010.05.024. Epub 2010 Jun 12.
Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated respiratory disease. The mRNA expressions of IL-1α and IL-8 were significantly up-regulated in pigs with PCV2-associated respiratory disease, while IL-10 expression was not detected. These results suggest that the increased expressions of proinflammatory cytokines in the lungs may play an important role in the immunopathologic response in pigs with PCV2-associated respiratory disease.
猪圆环病毒 2 型（PCV2）在全球范围内给养猪业带来了严重的健康问题。在本研究中，我们研究了与 PCV2 相关的呼吸道疾病猪肺部细胞因子表达谱（IFN-γ、IL-1α、IL-8 和 IL-10）。与 PCV2 相关的呼吸道疾病猪的 IL-1α 和 IL-8 mRNA 表达显著上调，而 IL-10 表达未检测到。这些结果表明，肺部促炎细胞因子的表达增加可能在与 PCV2 相关的呼吸道疾病猪的免疫病理反应中发挥重要作用。
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