药理剂量的抗坏血酸可抑制激素难治性前列腺癌的同种异体肿瘤生长和转移。
Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer.
机构信息
Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, USUHS, Bethesda, MD 20814, USA.
出版信息
In Vivo. 2010 May-Jun;24(3):249-55.
AIM
The aim of this study was to test for the influence of ascorbic acid on tumorigenicity and metastases of implanted PAIII prostate cancer adenocarcinoma cells in syngeneic LW rats.
MATERIALS AND METHODS
Hormone-refractory prostate cancer PAIII cells were implanted subcutaneously into immunologically intact, Lobund-Wistar (LW) rats. Intraperitoneal pharmacological doses of ascorbic acid were administered each day for the ensuing 30 days. On the 40th day, animals were sacrificed. Local tumor weights were measured, and metastases were counted.
RESULTS
At the end of the 40 day experimental period, the primary tumors were found to be significantly reduced in weight (p=0.026). In addition, sub-pleural lung metastases were even more profoundly reduced in number and size (p=0.009). Grossly enlarged ipsilateral lymph node metastases declined from 7 of 15 rats to 1 of 15 rats.
CONCLUSION
Pharmacological doses of ascorbic acid suppress tumor growth and metastases in hormone-refractory prostate cancer.
目的
本研究旨在检测抗坏血酸对同基因 LW 大鼠种植的 PAIII 前列腺癌腺癌肿瘤发生和转移的影响。
材料和方法
将激素难治性前列腺癌 PAIII 细胞皮下植入免疫完整的 Lobund-Wistar（LW）大鼠。在接下来的 30 天内，每天给予腹腔内药理剂量的抗坏血酸。第 40 天，处死动物。测量局部肿瘤重量，并计数转移灶。
结果
在 40 天的实验期末，原发性肿瘤的重量明显减轻（p=0.026）。此外，胸膜下肺转移灶的数量和大小也明显减少（p=0.009）。从 15 只大鼠中有 7 只大体增大的同侧淋巴结转移减少到 15 只大鼠中有 1 只。
结论
药理剂量的抗坏血酸可抑制激素难治性前列腺癌的肿瘤生长和转移。
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