Department of Materials and Structures, SINTEF Building and Infrastructure, Norwegian University of Science, and Technology, Trondheim, Norway.
Indoor Air. 2010 Aug;20(4):329-40. doi: 10.1111/j.1600-0668.2010.00658.x. Epub 2010 Apr 16.
In a nested case-control study with 198 children with asthmatic and allergic symptoms (cases) and 202 healthy controls in Värmland, Sweden, we have investigated the relationship between mold spore exposure (mean colony-forming unit) indoor and (i) different indexes of moldy odor indoor (observed by professional inspectors and reported by parents), (ii) visible signs of dampness in the homes of the children (observed and reported), and (iii) doctor-diagnosed asthma/allergy in children. No association was found between the spore concentration indoor and moldy odor and signs of visible dampness in the homes. When a semi-quantitative method in distinguishing between moldy houses or non-moldy houses was used, there were no significant differences between the observed indexes of moldy odor or visible signs of dampness (both observed and reported). No association could be found between the spore concentration in indoor air and asthma/allergy in the children.
Mold spore exposure indoor have been suggested as a possible explanation for airway problems such as asthma and allergy among people living in buildings with moisture-related problems. However, this investigation could not find any associations between the spore concentrations in indoor air and signs of dampness and moldy odor reported by parents or observed by professional inspectors. Neither was there any association between the indoor spore concentration and asthma/allergy among children. With these results, there is no reason for one-time air sampling of mold colony-forming unit (CFU) in indoor air of homes to identify risk factors for asthma/allergy in children living in Scandinavian countries.
在瑞典瓦尔姆兰的一项嵌套病例对照研究中,纳入了 198 名有哮喘和过敏症状的儿童(病例)和 202 名健康对照,我们研究了室内霉菌孢子暴露(平均集落形成单位)与(i)室内不同的霉菌气味指标(由专业检查员观察和家长报告),(ii)儿童家中可见的潮湿迹象(观察和报告),以及(iii)医生诊断的儿童哮喘/过敏之间的关系。室内孢子浓度与霉菌气味和家中可见的潮湿迹象之间没有关联。当使用区分发霉房屋或非发霉房屋的半定量方法时,观察到的霉菌气味指标或可见潮湿迹象(观察到和报告的)之间没有显著差异。室内空气中的孢子浓度与儿童哮喘/过敏之间也没有关联。
室内霉菌孢子暴露被认为是导致居住在与潮湿问题相关的建筑物中的人们出现气道问题(如哮喘和过敏)的一个可能原因。然而,这项调查未能发现室内空气中的孢子浓度与父母报告或专业检查员观察到的潮湿和发霉气味之间存在任何关联。室内孢子浓度与儿童哮喘/过敏之间也没有关联。根据这些结果,没有理由对居住在斯堪的纳维亚国家的儿童家中的室内空气进行一次性霉菌集落形成单位(CFU)空气采样,以确定哮喘/过敏的危险因素。