Pediatrics Infectious Diseases Research Center, Department of Pediatrics-Infectious Disease, Tehran University of Medical Sciences, No. 62 Gharib Street, Tehran, Iran.
Braz J Infect Dis. 2010 Mar-Apr;14(2):153-7. doi: 10.1590/s1413-86702010000200007.
Appropriate antimicrobial treatment of shigellosis depends on identifying its changing resistance pattern over time. We evaluated 15,255 stool culture submitted from July 2001 to June 2006 to the Laboratory of Children Medical Center Hospital. Specimen culture, bacterial identification, and disk diffusion susceptibility testing were performed according to National Committee for Clinical Laboratory Standards guidelines. From 15,255 stool samples, 682 (4.5%) were positive for Shigella species. The most common species of Shigella were S. flexneri (48%) and S. sonnei (45%); other results were S. dysenteriae (5%) and S. boydii (2%). The rate of sensitivity to ceftriaxone (95%), ceftizoxime (94%), and nalidixic acid (84%) were among our isolates. Resistance to co-trimoxazole and ampicillin was 87% and 86%, respectively. S. flexneri was more multiresistant than other species (47.9%). Our isolates are overall most sensitive to ceftriaxone, ceftazidime, and nalidixic acid (> 84%). They were most resistant to co-trimoxazole and ampicillin (> 86%). Because resistance varies according to specific location, continuous local monitoring of resistance patterns is necessary for the appropriate selection of empirical antimicrobial therapy.
志贺菌病的适当抗菌治疗取决于识别其随时间变化的耐药模式。我们评估了 2001 年 7 月至 2006 年 6 月向儿童医疗中心医院实验室提交的 15255 份粪便培养物。根据国家临床实验室标准委员会的指南进行了标本培养、细菌鉴定和药敏纸片扩散试验。从 15255 份粪便样本中，682 份（4.5%）志贺菌属阳性。最常见的志贺菌属是福氏志贺菌（48%）和宋内志贺菌（45%）；其他结果为痢疾志贺菌（5%）和鲍氏志贺菌（2%）。我们分离株对头孢曲松（95%）、头孢唑肟（94%）和萘啶酸（84%）的敏感性率较高。对复方磺胺甲噁唑和氨苄西林的耐药率分别为 87%和 86%。福氏志贺菌比其他种更具多耐药性（47.9%）。我们的分离株对头孢曲松、头孢他啶和萘啶酸最敏感（>84%）。它们对复方磺胺甲噁唑和氨苄西林最耐药（>86%）。由于耐药性因特定地点而异，因此需要持续进行当地耐药模式监测，以适当选择经验性抗菌治疗。
