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评价腰椎小关节神经阻滞治疗慢性下腰痛的效果:一项随机、双盲、对照临床试验,随访 2 年。

Evaluation of lumbar facet joint nerve blocks in managing chronic low back pain: a randomized, double-blind, controlled trial with a 2-year follow-up.

机构信息

Pain Management Center of Paducah, Paducah, KY, USA.

出版信息

Int J Med Sci. 2010 May 28;7(3):124-35. doi: 10.7150/ijms.7.124.

Abstract

STUDY DESIGN

A randomized, double-blind, controlled trial.

OBJECTIVE

To determine the clinical effectiveness of therapeutic lumbar facet joint nerve blocks with or without steroids in managing chronic low back pain of facet joint origin.

SUMMARY OF BACKGROUND DATA

Lumbar facet joints have been shown as the source of chronic pain in 21% to 41% of low back patients with an average prevalence of 31% utilizing controlled comparative local anesthetic blocks. Intraarticular injections, medial branch blocks, and radiofrequency neurotomy of lumbar facet joint nerves have been described in the alleviation of chronic low back pain of facet joint origin.

METHODS

The study included 120 patients with 60 patients in each group with local anesthetic alone or local anesthetic and steroids. The inclusion criteria was based upon a positive response to diagnostic controlled, comparative local anesthetic lumbar facet joint blocks.Outcome measures included the numeric rating scale (NRS), Oswestry Disability Index (ODI), opioid intake, and work status, at baseline, 3, 6, 12, 18, and 24 months.

RESULTS

Significant improvement with significant pain relief of >or= 50% and functional improvement of >or= 40% were observed in 85% in Group 1, and 90% in Group II, at 2-year follow-up.The patients in the study experienced significant pain relief for 82 to 84 weeks of 104 weeks, requiring approximately 5 to 6 treatments with an average relief of 19 weeks per episode of treatment.

CONCLUSIONS

Therapeutic lumbar facet joint nerve blocks, with or without steroids, may provide a management option for chronic function-limiting low back pain of facet joint origin.

摘要

研究设计

一项随机、双盲、对照试验。

目的

确定治疗性腰椎小关节神经阻滞联合或不联合类固醇治疗小关节源性慢性下腰痛的临床疗效。

背景资料概要

腰椎小关节已被证实为 21%至 41%慢性下腰痛患者的疼痛源,平均患病率为 31%,采用控制性对比局部麻醉阻滞。关节内注射、内侧支阻滞和腰椎小关节神经射频神经切断术已被用于缓解小关节源性慢性下腰痛。

方法

本研究纳入了 120 名患者,每组 60 名患者分别接受单纯局部麻醉或局部麻醉联合类固醇治疗。纳入标准为诊断性控制性对比局部麻醉腰椎小关节阻滞有阳性反应。主要观察指标包括数字评分量表(NRS)、Oswestry 残疾指数(ODI)、阿片类药物摄入量和工作状态,分别在基线、3、6、12、18 和 24 个月时进行评估。

结果

在第 2 年随访时,第 1 组 85%的患者和第 2 组 90%的患者观察到显著改善,疼痛缓解>50%,功能改善>40%。研究中的患者在 104 周中有 82 至 84 周经历了显著的疼痛缓解,需要大约 5 至 6 次治疗,每次治疗的平均缓解时间为 19 周。

结论

治疗性腰椎小关节神经阻滞联合或不联合类固醇可能为小关节源性慢性功能受限下腰痛的治疗提供一种选择。

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