Department of Obstetrics and Gynecology, Strong Memorial Hospital, University of Rochester, Rochester, NY 14642, USA.
Prenat Diagn. 2010 Sep;30(9):821-6. doi: 10.1002/pd.2554.
To determine the completion rate of ultrasound surveys for aneuploidy markers by maternal body mass index (BMI).
A retrospective review of ultrasounds on midtrimester singleton pregnancies was performed. Subjects were grouped as normal, overweight (BMI 25-29.9 kg/m(2)), and obese: class I (30-34.9 kg/m(2)), class II (35-39.9 kg/m(2)), and class III (>or= 40 kg/m(2)). Examinations with visualization of at least seven of eight markers were considered complete.
Of 14 353 ultrasounds reviewed, 5690 patients were eligible: 43% normal, 29% overweight, 27% obese. Completion rates differed significantly between groups (64% normal, 64% overweight, 61% class I, 55% class II, 47% class III, p < 0.001). The screen positive rates (>or=1 marker) differed significantly overall (16% normal, 13% overweight, 15% class I, 12% class II, 10% class III, p < 0.02), but not for complete examinations (p = 0.42).
Since completion rates for ultrasound aneuploidy screening are inversely related to maternal obesity, obese women are underscreened.
通过母体体重指数（BMI）确定非整倍体标志物超声检查的完成率。
对中期单胎妊娠的超声检查进行回顾性分析。将受试者分为正常、超重（BMI 25-29.9 kg/m(2)）和肥胖：I 级（30-34.9 kg/m(2)）、II 级（35-39.9 kg/m(2)）和 III 级（≥40 kg/m(2)）。如果至少可以看到 8 个标记物中的 7 个，则认为检查完整。
在审查的 14353 次超声检查中，有 5690 名患者符合条件：43%正常，29%超重，27%肥胖。各组之间的完成率差异有统计学意义（正常组为 64%，超重组为 64%，I 级肥胖组为 61%，II 级肥胖组为 55%，III 级肥胖组为 47%，p < 0.001）。总体而言，阳性检出率（≥1 个标记物）差异有统计学意义（正常组为 16%，超重组为 13%，I 级肥胖组为 15%，II 级肥胖组为 12%，III 级肥胖组为 10%，p < 0.02），但对于完整的检查则不然（p = 0.42）。
由于超声染色体异常筛查的完成率与母体肥胖呈反比，因此肥胖女性的筛查不足。
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