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CAPRI 轮 13-19 的目标。

The targets of CAPRI Rounds 13-19.

机构信息

Yeast Structural Genomics, IBBMC, Université Paris-Sud, Orsay, France.

出版信息

Proteins. 2010 Nov 15;78(15):3067-72. doi: 10.1002/prot.22774.

Abstract

Seven rounds of CAPRI predictions with a total of 14 targets were held in the period June 2007-November 2009. In addition to protease/inhibitor complexes and complexes with G-proteins, some of the targets displayed novel features presenting new challenges to the predictors: a complex with RNA, a leucine zipper to be built ab initio, and a human-designed protein. Nine targets were unbound or required model building; the other five had a bound component. Thirteen were assessed, and the results show that the predictor and scorer groups submitted two- or three-star (medium or high quality) models for eight of them, one-star (acceptable) models for three but failed on the unbound RNA complex and another unbound target.

摘要

CAPRI 预测挑战赛共进行了七轮,从 2007 年 6 月到 2009 年 11 月,总共有 14 个目标。除了蛋白酶/抑制剂复合物和与 G 蛋白的复合物外,一些目标还呈现出新的特征,给预测者带来了新的挑战:一个与 RNA 的复合物,一个从头开始构建的亮氨酸拉链,以及一个人类设计的蛋白质。九个目标是未结合或需要模型构建的;其余五个有结合的成分。其中 13 个目标进行了评估,结果表明,预测者和评分者小组为其中 8 个目标提交了两星或三星(中等或高质量)的模型,为 3 个目标提交了一星(可接受)的模型,但在未结合的 RNA 复合物和另一个未结合的目标上失败了。

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