胎儿心室舒张充盈特征在灵长类动物模型中的表现：胎儿心率和肺血管阻抗的作用。
Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance.
机构信息
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR 97239, USA.
出版信息
Reprod Sci. 2010 Aug;17(8):760-6. doi: 10.1177/1933719110370490.
OBJECTIVES
We hypothesized that fetal ventricular diastolic filling characteristics are related to fetal heart rate (FHR) and pulmonary vascular impedance.
METHODS
Rhesus monkeys underwent Doppler ultrasonography at near-term gestation. Tricuspid (TV) and mitral valve (MV) blood velocity waveforms were used to calculate maximum velocity (V-max) and velocity time integral (VTI) E/A ratios (early filling/ventricular filling during atrial contraction) at baseline and during maternal hyperoxygenation. Right pulmonary artery (RPA) pulsatility indices (PIs) and FHR were measured.
RESULTS
Hyperoxgenation significantly decreased FHR and RPA PI. The TV V-max and the MV VTI E/A ratios increased significantly and correlated with a decrease in FHR but not with a decrease in RPA PI. The TV and MV A-wave V-max decreased during hyperoxygenation and their decrease correlated significantly with a drop in FHR.
CONCLUSIONS
Fetal ventricular diastolic filling characteristics are related to FHR but not to pulmonary vascular impedance.
目的
我们假设胎儿心室舒张充盈特征与胎儿心率（FHR）和肺血管阻抗有关。
方法
恒河猴在接近足月时进行了多普勒超声检查。使用三尖瓣（TV）和二尖瓣（MV）血流速度波形来计算基线和母体高氧时的最大速度（V-max）和速度时间积分（VTI）E/A 比值（早期充盈/心房收缩期间的心室充盈）。测量右肺动脉（RPA）搏动指数（PI）和 FHR。
结果
高氧显著降低了 FHR 和 RPA PI。TV V-max 和 MV VTI E/A 比值显著增加，与 FHR 降低相关，但与 RPA PI 降低无关。TV 和 MV A 波 V-max 在高氧时降低，其降低与 FHR 显著下降相关。
结论
胎儿心室舒张充盈特征与 FHR 有关，但与肺血管阻抗无关。
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