海洋苔藓虫 Bugula neritina 中具有细胞毒性的新型含氧甾醇。

New cytotoxic oxygenated sterols from marine bryozoan Bugula neritina.

机构信息

Department of Pharmacy, Laboratory of Marine Drugs, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

出版信息

Nat Prod Res. 2011 Sep;25(16):1505-11. doi: 10.1080/14786410903211235. Epub 2011 Jul 11.

DOI:10.1080/14786410903211235

PMID:20602282

Abstract

Two new oxygenated sterols, 3β,24(S)-dihydroxycholesta-5,25-dien-7-one and 3β,25-dihydroxycholesta-5,23-dien-7-one, were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC₅₀ values between 22.58 and 53.41 µg mL⁻¹.

摘要

两种新型含氧甾醇，3β，24(S)-二羟基胆甾-5,25-二烯-7-酮和 3β，25-二羟基胆甾-5,23-二烯-7-酮，从海洋苔藓虫 Bugula neritina 中分离得到。它们的化学结构是基于光谱分析确定的。这两种化合物对三种人类癌细胞系（HepG2、HT-29 和 NCI-H460）表现出细胞毒性，IC₅₀ 值在 22.58 到 53.41 µg mL⁻¹ 之间。