伏隔核内侧基底杏仁核中的多巴胺 D1 受体介导海洛因引起的条件性免疫调节。
Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation.
机构信息
Department of Psychology, CB#3270, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3270, USA.
出版信息
J Neuroimmunol. 2010 Sep 14;226(1-2):38-47. doi: 10.1016/j.jneuroim.2010.05.029. Epub 2010 Jun 3.
Abstract
This study investigates the role of basolateral amygdala (BLA) dopamine in heroin-induced conditioned immunomodulation. Animals underwent conditioning in which heroin administration was repeatedly paired with placement into a conditioning chamber. Six days after the final conditioning session animals were returned to the chamber and received intra-BLA microinfusions of dopamine, D(1) or D(2), antagonist. Antagonism of D(1), but not D(2), receptors within the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS, TNF-α and IL-1β. This study is the first to demonstrate that the expression of heroin's conditioned effects on proinflammatory mediators require dopamine D(1) receptors within the BLA.
摘要
这项研究调查了伏隔核（BLA）多巴胺在海洛因引起的条件性免疫调节中的作用。动物接受了条件作用训练，即在重复给予海洛因的同时将其放入一个条件箱中。最后一次条件作用训练六天后，动物被放回箱中，并接受了 BLA 内多巴胺、D1 或 D2 拮抗剂的微灌注。BLA 内 D1 受体而非 D2 受体的拮抗作用阻断了海洛因相关环境刺激对 iNOS、TNF-α 和 IL-1β 的抑制作用。这项研究首次证明，海洛因对促炎介质的条件作用的表达需要 BLA 内的多巴胺 D1 受体。
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