Northwestern University Medical School, Chicago, IL, USA.
Clin Cancer Res. 2010 Sep 1;16(17):4311-2. doi: 10.1158/1078-0432.CCR-10-1496. Epub 2010 Jul 9.
Simultaneous targeting of the phosphoinositide 3-kinase (PI3K)/Akt pathway increases arsenic trioxide (ATO)-dependent cytotoxicity of chronic lymphocytic leukemia (CLL) cells, whereas it has no significant effects on normal lymphocytes. Combinations of ATO with small molecules that target PI3K and/or Akt may provide a novel approach for the treatment of CLL.
同时靶向磷酸肌醇 3-激酶(PI3K)/Akt 通路可增加三氧化二砷(ATO)对慢性淋巴细胞白血病(CLL)细胞的细胞毒性,而对正常淋巴细胞则没有显著影响。ATO 与靶向 PI3K 和/或 Akt 的小分子联合使用可能为 CLL 的治疗提供新的方法。