日本社区阿尔茨海默病和血管性痴呆患病率的趋势：久山研究。
Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study.
机构信息
Department of Environmental Medicine, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka City, Japan.
出版信息
Acta Psychiatr Scand. 2010 Oct;122(4):319-25. doi: 10.1111/j.1600-0447.2010.01587.x. Epub 2010 Jul 9.
OBJECTIVE
To examine secular trends in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) in a general Japanese population.
METHOD
Four cross-sectional examinations were conducted among residents of a Japanese community aged >or=65 in 1985, 1992, 1998 and 2005.
RESULTS
The age- and sex-adjusted prevalence of all-cause dementia significantly increased with time (6.0% in 1985, 4.4% in 1992, 5.3% in 1998 and 8.3% in 2005; P for trend = 0.002). A similar trend was observed for AD (1.1%, 1.3%, 2.3% and 3.8% respectively; P for trend < 0.001), while the age- and sex-adjusted prevalence of VD and other/unclassified dementia showed J-shaped patterns (for VD: 2.3%, 1.5%, 1.5% and 2.5%, respectively, P for trend = 0.82; for other/unclassified dementia: 2.6%, 1.7%, 1.5% and 2.0%, P for trend = 0.26). The prevalence of AD was likely to increase with time from 1985 to 2005 among subjects aged 75 or older. The ratio of the prevalence of VD to that of AD decreased with time (2.1 in 1985, 1.2 in 1992, 0.7 in 1998 and 0.7 in 2005).
CONCLUSION
Our findings suggest that the prevalence of all-cause dementia and AD significantly increased over the past two decades in the general Japanese population.
目的
在日本一般人群中研究阿尔茨海默病（AD）和血管性痴呆（VD）的流行趋势随时间的变化。
方法
1985 年、1992 年、1998 年和 2005 年，对居住在一个日本社区中年龄≥65 岁的居民进行了 4 次横断面研究。
结果
经过年龄和性别调整后，所有原因引起的痴呆的患病率随时间显著增加（1985 年为 6.0%，1992 年为 4.4%，1998 年为 5.3%，2005 年为 8.3%；趋势 P 值=0.002）。AD 也观察到了类似的趋势（分别为 1.1%、1.3%、2.3%和 3.8%；趋势 P 值<0.001），而 VD 和其他/未分类痴呆的年龄和性别调整后的患病率呈 J 形模式（VD 分别为 2.3%、1.5%、1.5%和 2.5%，趋势 P 值=0.82；其他/未分类痴呆为 2.6%、1.7%、1.5%和 2.0%，趋势 P 值=0.26）。在 75 岁及以上的人群中，AD 的患病率可能会随着时间从 1985 年到 2005 年增加。VD 与 AD 的患病率之比随时间下降（1985 年为 2.1，1992 年为 1.2，1998 年为 0.7，2005 年为 0.7）。
结论
我们的发现表明，在过去的二十年中，日本一般人群中所有原因引起的痴呆和 AD 的患病率显著增加。
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