多发性硬化的周围神经系统受累。
Peripheral nervous system involvement in multiple sclerosis.
机构信息
Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Essen, Germany.
出版信息
Eur J Neurol. 2011 May;18(5):789-91. doi: 10.1111/j.1468-1331.2010.03149.x.
OBJECTIVE
To investigate possible peripheral nervous system (PNS) affection in patients with multiple sclerosis (MS) by standard nerve conduction velocity (SNC) and pain-related evoked potentials (PREP), a novel electrophysiological method for diagnosing small fibre neuropathy.
BACKGROUND
Former neuropathological and electrophysiological studies demonstrated subtle PNS affection in MS, but routine measurements are mostly normal. Small fibre polyneuropathy is associated with several autoimmune diseases but has not been investigated in MS yet.
DESIGN/METHODS: Fifty-four patients with MS (43 relapsing-remitting, 11 secondary progressive MS) underwent SNC of the tibial, sural and peroneal nerve. Twenty-one patients additionally underwent PREP.
RESULTS
SNC abnormalities were observed in 29.6% of all patients and 14.2% of all nerves examined No abnormalities on PREP were found.
CONCLUSIONS/RELEVANCE: We demonstrated subtle alterations on routine electrophysiological measurements in patients with MS without hints for small fibre pathology.
目的
通过标准神经传导速度（SNC）和疼痛相关诱发电位（PREP）研究多发性硬化症（MS）患者可能存在的周围神经系统（PNS）病变，PREP 是一种用于诊断小纤维神经病的新型电生理学方法。
背景
先前的神经病理学和电生理学研究表明 MS 存在细微的 PNS 病变，但常规测量大多正常。小纤维多发性神经病与几种自身免疫性疾病有关，但尚未在 MS 中进行研究。
设计/方法：54 例 MS 患者（43 例复发缓解型，11 例继发进展型 MS）接受了胫神经、腓肠神经和腓总神经的 SNC 检查。21 例患者另外进行了 PREP 检查。
结果
所有患者中有 29.6%出现 SNC 异常，所有检查神经中有 14.2%出现异常。未发现 PREP 异常。
结论/相关性：我们在无小纤维病理迹象的 MS 患者中发现了常规电生理测量的细微改变。
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