基于表面等离子体共振的高灵敏度石墨烯生物传感器。

Highly sensitive graphene biosensors based on surface plasmon resonance.

作者信息

Wu L, Chu H S, Koh W S, Li E P

机构信息

Advanced Photonics and Plasmonics Group, A*STAR Institute of High Performance Computing, 138632, Singapore.

出版信息

Opt Express. 2010 Jul 5;18(14):14395-400. doi: 10.1364/OE.18.014395.

DOI:10.1364/OE.18.014395

PMID:20639924

Abstract

A surface plasmon resonance (SPR) based graphene biosensor is presented. It consists of a graphene sheet coated above a gold thin film, which has been proposed and experimentally fabricated recently [ChemPhysChem 11, 585 (2010)]. The biosensor uses attenuated total reflection (ATR) method to detect the refractive index change near the sensor surface, which is due to the adsorption of biomolecules. Our calculations show that the proposed graphene-on-gold SPR biosensor (with L graphene layers) is (1 + 0.025 L) x gamma (where gamma > 1) times more sensitive than the conventional gold thin film SPR biosensor. The improved sensitivity is due to increased adsorption of biomolecules on graphene (represented by the factor gamma) and the optical property of graphene.

摘要

提出了一种基于表面等离子体共振（SPR）的石墨烯生物传感器。它由涂覆在金薄膜上方的石墨烯片组成，这是最近有人提出并通过实验制备的[《化学物理化学》11, 585 (2010)]。该生物传感器采用衰减全反射（ATR）方法来检测传感器表面附近由于生物分子吸附而引起的折射率变化。我们的计算表明，所提出的金上石墨烯SPR生物传感器（具有L层石墨烯）比传统的金薄膜SPR生物传感器敏感(1 + 0.025L)×γ倍（其中γ>1）。灵敏度的提高归因于石墨烯上生物分子吸附的增加（由因子γ表示）以及石墨烯的光学性质。