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[成人神经脑膜李斯特菌感染。临床、生物学及治疗方面。附36例报告]

[Neuromeningeal Listeria infections in adults. Clinical, biological and therapeutic aspects. Apropos of 36 cases].

作者信息

Lazanas M, Perronne C, Leport C, Salmon-Ceron D, Bricaire F, Vilde J L

机构信息

Service des Maladies Infectieuses et Tropicales, Hôpital Claude-Bernard, Paris.

出版信息

Ann Med Interne (Paris). 1991;142(2):95-8.

PMID:2064172
Abstract

In this retrospective study, 36 cases of Listeria monocytogenes meningitis were reviewed. A bacteriological confirmation was obtained for every patient either by lombar puncture or blood culture. The clinical picture and the composition of the cerebrospinal fluid were polymorphous. Most patients were previously in good health, while 10 of them (28%) had a predisposing factor: pregnancy, gastrectomy, diabetes mellitus, alcoholism or immunosuppression. The outcome was favorable in 23 patients (64%); 8 patients were cured with sequelae (22%); 5 patients died (14%). Death occurred in patients suffering from concomitant underlying disease, such as coronary insufficiency (n = 1) or immunosuppression (n = 2), or in the case of delayed diagnosis and treatment (n = 2).

摘要

在这项回顾性研究中,对36例单核细胞增生李斯特菌脑膜炎病例进行了分析。所有患者均通过腰椎穿刺或血培养获得细菌学确诊。脑脊液的临床表现和成分具有多态性。大多数患者此前身体健康,其中10例(28%)有易感因素:妊娠、胃切除术、糖尿病、酗酒或免疫抑制。23例患者(64%)预后良好;8例患者治愈后有后遗症(22%);5例患者死亡(14%)。死亡发生在患有诸如冠状动脉供血不足(n = 1)或免疫抑制(n = 2)等伴随基础疾病的患者中,或发生在诊断和治疗延迟的情况下(n = 2)。

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