刚地弓形虫亲环蛋白18调节小鼠巨噬细胞和脾细胞的增殖与迁移。
Toxoplasma gondii cyclophilin 18 regulates the proliferation and migration of murine macrophages and spleen cells.
作者信息
Ibrahim Hany M, Xuan Xuenan, Nishikawa Yoshifumi
机构信息
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, Japan.
出版信息
Clin Vaccine Immunol. 2010 Sep;17(9):1322-9. doi: 10.1128/CVI.00128-10. Epub 2010 Jul 21.
Toxoplasma gondii is an intracellular parasite that shows a unique capacity to infect a variety of cell types in warm-blooded animals. It can invade and survive well inside immune cells, such as macrophages, that disseminate the parasite around the body because of their migratory properties. The aim of the present study was to evaluate the role of T. gondii cyclophilin 18 (TgCyp18) in the proliferation and migration of macrophages and spleen cells (mainly T lymphocytes) in order to understand the effects of TgCyp18 on the dynamics of the infection. A high dose of TgCyp18 enhanced the proliferation of macrophages and spleen cells in a cysteine-cysteine chemokine receptor 5 (CCR5)-independent way. In contrast, TgCyp18 controlled the migration of macrophages and spleen cells in dose- and CCR5-dependent manners. Our data suggest that TgCyp18 recruits cells and enhances the growth of host cells at the site of infection for maintenance of the interaction between the parasite and host.
刚地弓形虫是一种细胞内寄生虫，具有独特的能力来感染温血动物的多种细胞类型。它能够侵入免疫细胞（如巨噬细胞）并在其中良好存活，由于巨噬细胞的迁移特性，会将寄生虫传播至全身。本研究的目的是评估刚地弓形虫亲环蛋白18（TgCyp18）在巨噬细胞和脾细胞（主要是T淋巴细胞）增殖和迁移中的作用，以便了解TgCyp18对感染动态的影响。高剂量的TgCyp18以不依赖于半胱氨酸-半胱氨酸趋化因子受体5（CCR5）的方式增强巨噬细胞和脾细胞的增殖。相反，TgCyp18以剂量和CCR5依赖的方式控制巨噬细胞和脾细胞的迁移。我们的数据表明，TgCyp18在感染部位募集细胞并增强宿主细胞的生长，以维持寄生虫与宿主之间的相互作用。
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