自发性糖尿病 Torii-Lepr(fa)大鼠血压的评估。

Evaluation of blood pressure in Spontaneously Diabetic Torii-Lepr(fa) rats.

机构信息

Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka, Japan.

出版信息

Exp Anim. 2010;59(4):525-9. doi: 10.1538/expanim.59.525.

DOI:10.1538/expanim.59.525

PMID:20661000

Abstract

The Spontaneously Diabetic Torii-Lepr(fa) (SDT-fa/fa) rat, a new model of obese type 2 diabetes, shows obesity, hyperglycemia, and hyperlipidemia from 6 weeks of age. Diabetic complications such as nephropathy and cataract are observed with aging; however, blood pressure change with age has not previously been examined. In this study, blood pressure was periodically measured and the change was investigated. Blood pressure in male SDT-fa/fa rats was elevated at 8, 16, and 24 weeks of age, whereas the heart rate was not changed. In addition to hyperglycemia, hyperlipidemia, and proteinuria, hyperleptinemia and increased urine angiotensinogen were observed in SDT-fa/fa rats. Blood pressure and heart rate in the male original SDT (SDT-+/+) rat did not significantly change. In conclusion, the SDT-fa/fa rat is a promising model, showing significant hypertension with diabetes mellitus.

摘要

自发性糖尿病 Torii-Lepr(fa) (SDT-fa/fa) 大鼠，一种肥胖 2 型糖尿病的新型模型，从 6 周龄开始表现出肥胖、高血糖和高血脂。随着年龄的增长，会出现肾病和白内障等糖尿病并发症；然而，以前没有检查过血压随年龄的变化。在这项研究中，周期性地测量血压并研究了其变化。雄性 SDT-fa/fa 大鼠的血压在 8、16 和 24 周龄时升高，而心率没有变化。除了高血糖、高血脂和蛋白尿外，SDT-fa/fa 大鼠还表现出高瘦素血症和尿血管紧张素原增加。雄性原始 SDT (SDT-+/+) 大鼠的血压和心率没有显著变化。总之，SDT-fa/fa 大鼠是一种有前途的模型，表现出与糖尿病相关的显著高血压。