原发性乳腺小细胞癌伴TTF-1及神经内分泌标志物表达的原位癌
Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ.
作者信息
Christie Michael, Chin-Lenn Laura, Watts Monique M, Tsui Alpha E, Buchanan Malcolm R
机构信息
Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
出版信息
Int J Clin Exp Pathol. 2010 Jun 30;3(6):629-33.
Abstract
Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from metastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinoma of the breast with coexisting carcinoma in situ in which the invasive carcinoma and in situ component both expressed neuroendocrine markers and Thyroid transcription factor-1 (TTF-1) by immunohistochemistry. Expression of neuroendocrine markers and TTF-1 in the in situ component allowed a highly confident diagnosis of primary small cell carcinoma of the breast. To our knowledge there is only one previous report of TTF-1 expressing in situ carcinoma associated with a primary SmCC of the breast.
摘要
原发性乳腺小细胞癌（SmCC）非常罕见，可能难以与转移性小细胞癌区分开来。原发性乳腺SmCC的可靠组织病理学诊断需要证明存在原位成分。我们报告一例原发性乳腺小细胞癌合并原位癌的病例，其中浸润性癌和原位成分通过免疫组织化学均表达神经内分泌标志物和甲状腺转录因子-1（TTF-1）。原位成分中神经内分泌标志物和TTF-1的表达使得对原发性乳腺小细胞癌的诊断高度可靠。据我们所知，之前仅有一篇关于TTF-1表达的原位癌与原发性乳腺SmCC相关的报道。
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