鼻窦内肠型腺癌在木材和皮革工人中的回顾性研究：153 例报告。

Intestinal type adenocarcinoma of the ethmoid sinus in wood and leather workers: a retrospective study of 153 cases.

机构信息

Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milan, Italy.

出版信息

Head Neck. 2011 Apr;33(4):535-42. doi: 10.1002/hed.21485.

DOI:10.1002/hed.21485

PMID:20665741

Abstract

BACKGROUND

The purpose of our study was to identify the role of work exposure to organic dusts in patients with malignant paranasal sinus tumors.

METHODS

We analyzed all patients surgically treated for a malignant paranasal sinus tumor at our institution between 1987 and 2006. All patients were specifically asked about their occupational history. The tumor site was classified as maxillary or ethmoid sinus. Adenocarcinomas were divided into intestinal type (ITAC) and non-ITAC.

RESULTS

The sample included 345 patients with ethmoid sinus and 301 maxillary sinus. Regarding the ethmoid sinus, we found an exposure to organic dusts in 148 of 153 patients with ITAC, in 3 of 16 patients with non-ITAC adenocarcinoma, and in 10 of 176 patients with other tumors. Regarding the maxillary sinus, we found an exposure in 1 of 20 patients with non-ITAC adenocarcinoma and in 4 of 281 patients with other histologies.

CONCLUSION

Our study demonstrates that only ethmoid ITACs have an indisputable relationship with the exposure to organic dusts.

摘要

背景

我们研究的目的是确定工作中接触有机粉尘在恶性鼻旁窦肿瘤患者中的作用。

方法

我们分析了 1987 年至 2006 年间在我们机构接受恶性鼻旁窦肿瘤手术治疗的所有患者。所有患者都被专门询问了他们的职业史。肿瘤部位分为上颌窦或筛窦。腺癌分为肠型（ITAC）和非-ITAC。

结果

样本包括 345 例筛窦和 301 例上颌窦患者。对于筛窦，我们发现 153 例 ITAC 中有 148 例、16 例非-ITAC 腺癌中有 3 例、176 例其他肿瘤中有 10 例接触过有机粉尘。对于上颌窦，我们发现 20 例非-ITAC 腺癌中有 1 例、281 例其他组织学中有 4 例接触过有机粉尘。