Stenstrøm Anne Dorte, Christiansen Erik, Dehlholm-Lambertsen Birgitte, Nøhr-Jensen Peer, Bilenberg Niels
Psykiatrien i Region Syddanmark, BUP Kolding, 6000 Kolding.
Ugeskr Laeger. 2010 Aug 2;172(31):2131-5.
The purpose was to expand the understanding of schizophrenia development in children and adolescents. An age- and gender-specific analysis of children and adolescents diagnosed with schizophrenia (F20.xx) was performed. The analysis included calculation of incidence rates of schizophrenia, schizophrenia subtypes, and an account of occurrence of any registered psychiatric diagnoses prior to first schizophrenia diagnosis.
Patients aged 0-21 years diagnosed with schizophrenia (F20.xx) and registered in the Danish Psychiatric Central Research Register in 1994-2007 were included.
The cohort consisted of 3,065 patients aged 6-21 years. Incidence rates vary with age and gender, and have been increasing in recent years. Boys have earlier onset and higher incidence rates than girls. The most common schizophrenia subtypes were paranoid (F20.0; 44.0%) and unspecified (F20.9; 28.7%). Three in every four patients had contact with the psychiatric hospital system prior to first schizophrenia diagnosis.
Schizophreniform symptomatology tends to overlap with other psychiatric disorders, and diagnostic stability is low. The diagnosis schizophrenia should be systematically included in diagnostic deliberations. Qualitative studies describing and analysing early psychopathology in children and adolescents with schizophrenia will improve the present knowledge.
目的是拓展对儿童和青少年精神分裂症发病情况的理解。对诊断为精神分裂症(F20.xx)的儿童和青少年进行了年龄和性别特异性分析。分析包括精神分裂症发病率、精神分裂症亚型的计算,以及首次精神分裂症诊断之前任何已登记精神科诊断的发生情况。
纳入1994年至2007年在丹麦精神病学中央研究登记处登记的0至21岁诊断为精神分裂症(F20.xx)的患者。
该队列由3065名6至21岁的患者组成。发病率随年龄和性别而变化,且近年来一直在上升。男孩起病更早,发病率高于女孩。最常见的精神分裂症亚型是偏执型(F20.0;44.0%)和未特定型(F20.9;28.7%)。四分之三的患者在首次精神分裂症诊断之前曾与精神病医院系统接触。
精神分裂症样症状往往与其他精神障碍重叠,诊断稳定性较低。在诊断考虑中应系统纳入精神分裂症的诊断。描述和分析精神分裂症儿童和青少年早期精神病理学的定性研究将增进当前的认识。