英格兰东北部农村地区帕金森病的患病率。

The prevalence of Parkinson's disease in a rural area of North-East England.

机构信息

Department of Medicine, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear NE28 9NH, UK.

出版信息

Parkinsonism Relat Disord. 2010 Nov;16(9):572-5. doi: 10.1016/j.parkreldis.2010.07.002. Epub 2010 Jul 31.

DOI:10.1016/j.parkreldis.2010.07.002

PMID:20674462

Abstract

AIMS AND OBJECTIVES

We have previously reported the age-adjusted prevalence of idiopathic Parkinson's disease (PD) in North Tyneside, an urban area of North-East England, as 139 cases (95% CI 116 to 162) per 100,000. The aim of this study was to report the prevalence of idiopathic PD in a rural area of North-East England.

METHODS

The same case-finding methodology as that employed in North Tyneside was used to identify cases of PD in an area of North Northumberland with a population of 59,613 at the 2001 UK census. All GPs in the study area were asked to provide details of patients registered with their service that may have PD or were on PD medication. Furthermore, all patients registered with the local PD service or under the care of a consultant neurologist or other relevant secondary care specialist were considered for inclusion. Inclusion in the study required fulfillment of the UK Brain Bank criteria.

RESULTS

One-hundred-and-six cases were identified (50 women and 56 men), giving crude and age-adjusted prevalence estimates of 178 cases (95% CI 144 to 212) and 142 cases (95% CI 118 to 165) per 100,000 respectively. The age-adjusted prevalence rate within our rural study area was remarkably similar to that seen in other urban UK studies. Only 71 cases (67.0%) were identified through GP records.

CONCLUSIONS

The prevalence of PD rural and urban areas of North-East England is remarkably similar.

摘要

目的和目标

我们之前报道了英格兰东北部泰恩赛德市（North Tyneside）的特发性帕金森病（PD）年龄调整患病率为每 10 万人中有 139 例（95%CI 116 至 162）。本研究的目的是报告英格兰东北部农村地区特发性 PD 的患病率。

方法

采用与泰恩赛德市相同的病例发现方法，在诺森伯兰郡北部的一个地区（2001 年英国人口普查时人口为 59613 人）识别 PD 病例。要求研究区域内的所有全科医生提供其服务中可能患有 PD 或正在服用 PD 药物的患者的详细信息。此外，所有在当地 PD 服务机构登记或在顾问神经科医生或其他相关二级保健专家的护理下的患者都被认为有资格参加。参加研究需要符合英国脑库标准。

结果

共发现 106 例病例（50 名女性和 56 名男性），粗患病率和年龄调整后患病率估计值分别为 178 例（95%CI 144 至 212）和 142 例（95%CI 118 至 165）每 10 万人。我们农村研究区域的年龄调整患病率与其他英国城市研究中观察到的患病率非常相似。仅通过全科医生记录发现了 71 例（67.0%）病例。