Akoury H A, MacDonald F J, Brodie G, Caddick R, Chaudhry N M, Frize M
Department of Obstetrics and Gynecology, Moncton Hospital, New Brunswick, Canada.
Obstet Gynecol. 1991 Aug;78(2):227-30.
Recent pharmacologic observations in vivo suggest the use of a lower starting dose (0.5-0.1 mU/minute) of oxytocin and a longer interval between dose augmentations (30-60 minutes) than previously advocated. In this study, a high-dose oxytocin protocol was used to augment nonprogressive labor in normal nulliparous women. The rate of oxytocin infusion started at 6 mU/minute and was increased by 6 mU/minute every 15 minutes to a maximum dose of 40 mU/minute. Charts were reviewed of 1080 nulliparous women for whom the principles of active management of labor were followed and delivery occurred between March 1, 1986 and December 31, 1988. Four hundred fifty-six who required oxytocin augmentation in labor were compared with 624 who did not receive oxytocin. There were no statistically significant differences in birth asphyxia or perinatal morbidity.
近期的体内药理学观察表明，催产素起始剂量应降低（0.5 - 0.1 毫国际单位/分钟），且剂量增加间隔应延长（30 - 60 分钟），这与先前的主张不同。在本研究中，采用高剂量催产素方案来加强正常初产妇的产程进展缓慢情况。催产素输注速率起始为 6 毫国际单位/分钟，每 15 分钟增加 6 毫国际单位/分钟，直至最大剂量 40 毫国际单位/分钟。回顾了 1080 例初产妇的图表，这些产妇遵循了积极产程管理原则，且分娩时间在 1986 年 3 月 1 日至 1988 年 12 月 31 日之间。将 456 例产程中需要催产素加强的产妇与 624 例未接受催产素的产妇进行比较。出生窒息或围产期发病率方面无统计学显著差异。
