State Key Laboratory for Infectious Disease Control and Prevention, Beijing, People's Republic of China.
Emerg Infect Dis. 2010 Aug;16(8):1195-203. doi: 10.3201/eid1608.090470.
Hemorrhagic fever with renal syndrome (HFRS) is a serious public health problem in the People's Republic of China. Although 7 sero/genotypes of hantaviruses have been found in rodents, only Hantaan virus (carried by Apodemus agrarius mice) and Seoul virus (carried by Rattus norvegicus rats) reportedly cause disease in humans. During 1950-2007, a total of 1,557,622 cases of HFRS in humans and 46,427 deaths (3%) were reported in China. HFRS has been reported in 29 of 31 provinces in China. After implementation of comprehensive preventive measures, including vaccination, in the past decade in China, incidence of HFRS has dramatically decreased; only 11,248 HFRS cases were reported in 2007. Mortality rates also declined from the highest level of 14.2% in 1969 to ?1% during 1995-2007. However, the numbers of HFRS cases and deaths in China remain the highest in the world.
肾综合征出血热（HFRS）是中华人民共和国的一个严重公共卫生问题。虽然已在啮齿动物中发现了 7 种血清/基因型的汉坦病毒，但据报道只有汉滩病毒（由黑线姬鼠携带）和汉城病毒（由褐家鼠携带）会导致人类患病。1950 年至 2007 年期间，中国共报告了 1557622 例人类肾综合征出血热病例和 46427 例死亡（3%）。HFRS 在中国 31 个省中的 29 个省都有报告。在过去十年中，中国实施了包括疫苗接种在内的综合预防措施后，HFRS 的发病率大幅下降；2007 年仅报告了 11248 例 HFRS 病例。死亡率也从 1969 年的最高水平 14.2%下降到 1995-2007 年期间的 1%。然而，中国的 HFRS 病例和死亡人数仍居世界首位。
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