Collado A, Sanmarti R, Serra C, Gallart T, Cañeté J D, Gratacos J, Vives J, Muñoz-Gomeź J
Department of Rheumatology, Hospital Clinic i Provincial de Barcelona, Spain.
Scand J Rheumatol. 1991;20(3):153-8. doi: 10.3109/03009749109103015.
An ELISA test was performed in order to measure the serum levels of secretory IgA (sIgA) in 51 patients with ankylosing spondylitis (AS) and 30 healthy controls. Raised values of sIgA were found in AS patients compared to controls. Patients with active disease, defined by clinical criteria, showed a significant elevation of serum sIgA compared to healthy controls (p = 0.03) or to patients with inactive disease (p = 0.02). A positive correlation between total serum IgA and sIgA was found (p = 0.001). Our findings further support the role of the mucosal stimulation in the pathogenesis of AS.
为了测量51例强直性脊柱炎（AS）患者和30名健康对照者血清中分泌型IgA（sIgA）的水平，进行了酶联免疫吸附测定（ELISA）试验。与对照组相比，AS患者的sIgA值升高。根据临床标准定义的活动期疾病患者，其血清sIgA水平与健康对照者相比显著升高（p = 0.03），与非活动期疾病患者相比也显著升高（p = 0.02）。发现血清总IgA与sIgA之间存在正相关（p = 0.001）。我们的研究结果进一步支持了黏膜刺激在AS发病机制中的作用。
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