妊娠期血栓预防：谁和如何预防？

Thromboprophylaxis in pregnancy: who and how?

机构信息

Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, UT 84132, USA.

出版信息

Obstet Gynecol Clin North Am. 2010 Jun;37(2):333-43. doi: 10.1016/j.ogc.2010.02.004.

DOI:10.1016/j.ogc.2010.02.004

PMID:20685557

Abstract

Venous thrombosis and embolism (VTE) is one of the most common, serious complications associated with pregnancy, and now ranks as a leading cause of maternal morbidity and mortality in developed countries. Information regarding the association of VTE with acquired and heritable thrombophilias has greatly expanded in the last 20 years, adding a new layer of complexity to decisions about thromboprophylaxis. The objective of this review is to detail which patients are at clinically important increased risk for VTE, are candidates for thrombophilia screening, and warrant thromboprophylaxis. Recommended management regimens for use in specific patient subgroups are also provided.

摘要

静脉血栓栓塞症（VTE）是妊娠最常见且严重的并发症之一，目前已成为发达国家产妇发病率和死亡率的主要原因之一。过去 20 年来，有关 VTE 与获得性和遗传性血栓形成倾向之间关系的信息大大增加，这使得在决定血栓预防措施方面增加了新的复杂性。本综述的目的是详细说明哪些患者存在临床意义上的 VTE 风险增加，是血栓形成倾向筛查的候选者，并需要进行血栓预防。还提供了用于特定患者亚组的推荐管理方案。