幽门螺杆菌临床分离株致病机制的分子基础。
Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates.
机构信息
Laboratório de Biologia Molecular, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.
出版信息
J Clin Microbiol. 2010 Oct;48(10):3776-8. doi: 10.1128/JCM.00472-10. Epub 2010 Aug 4.
Abstract
This study identified pathogenicity genes in 40 Helicobacter pylori clinical isolates. The cagA, vacA, and iceA genes were detected in 65%, 97.5%, and 97.5% of the isolates, respectively. The cagA, iceA1, and vacAs1a/m1 genes were related to erosive gastritis, whereas the vacAs2/m2 and iceA2 genes were associated with enanthematous gastritis.
摘要
本研究鉴定了 40 株幽门螺杆菌临床分离株中的致病性基因。cagA、vacA 和 iceA 基因在分别在 65%、97.5%和 97.5%的分离株中被检出。cagA、iceA1 和 vacAs1a/m1 基因与侵蚀性胃炎有关，而 vacAs2/m2 和 iceA2 基因与充血性胃炎有关。
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本文引用的文献
1
Detection of Helicobacter pylori by phenotypic and genotypic methods.
Dig Dis Sci. 2010 Jun;55(6):1643-8. doi: 10.1007/s10620-009-0928-8. Epub 2009 Aug 20.
2
Prevalence of virulence-associated genotypes of Helicobacter pylori and correlation with severity of gastric pathology in patients from western Sicily, Italy.
Eur J Clin Microbiol Infect Dis. 2009 May;28(5):437-46. doi: 10.1007/s10096-008-0644-x. Epub 2008 Oct 29.
3
Direct detection and analysis of vacA genotypes and cagA gene of Helicobacter pylori from gastric biopsies by a novel multiplex polymerase chain reaction assay.
Diagn Microbiol Infect Dis. 2008 Dec;62(4):366-73. doi: 10.1016/j.diagmicrobio.2008.07.014. Epub 2008 Oct 7.
4
H pylori iceA alleles are disease-specific virulence factors.
World J Gastroenterol. 2007 May 14;13(18):2581-5. doi: 10.3748/wjg.v13.i18.2581.
5
Association between Helicobacter pylori genotypes and gastric disorders in relation to the cag pathogenicity island.
Diagn Microbiol Infect Dis. 2007 Sep;59(1):7-16. doi: 10.1016/j.diagmicrobio.2007.03.019. Epub 2007 May 22.
6
Helicobacter pylori detection and antimicrobial susceptibility testing.
Clin Microbiol Rev. 2007 Apr;20(2):280-322. doi: 10.1128/CMR.00033-06.
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Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases.
Acta Trop. 2006 Dec;100(3):232-40. doi: 10.1016/j.actatropica.2006.08.014. Epub 2006 Dec 19.
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No correlation of babA2 with vacA and cagA genotypes of Helicobacter pylori and grading of gastritis from peptic ulcer disease patients in Brazil.
Helicobacter. 2005 Dec;10(6):601-8. doi: 10.1111/j.1523-5378.2005.00360.x.
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Diagn Microbiol Infect Dis. 2005 Apr;51(4):231-5. doi: 10.1016/j.diagmicrobio.2004.11.007.
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