Brody School of Medicine, East Caroline University, Greenville, North Carolina 27834, USA.
Annu Rev Physiol. 2011;73:515-25. doi: 10.1146/annurev-physiol-042210-121137.
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide. However, the mechanisms by which clots are formed in the deep veins have not been determined. Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into the circulation on small-membrane vesicles termed microparticles (MPs). Recent studies suggest that elevated levels of MP TF may trigger thrombosis. This review provides an overview of the role of TF in VTE.
静脉血栓栓塞症(VTE)是全球发病率和死亡率的主要原因。然而,深静脉血栓形成的机制尚未确定。组织因子(TF)是凝血级联反应的主要启动子,对止血至关重要。在病理条件下,TF 从小膜囊泡(微泡)释放到循环中,称为微颗粒(MPs)。最近的研究表明,MP TF 水平升高可能引发血栓形成。本综述概述了 TF 在 VTE 中的作用。