De Luis D A, González Sagrado M, Conde R, Aller R, Izaola O
Instituto de Endocrinología y Nutrición Clínica, Medicine School, Valladolid University, Valladolid, Spain.
Nutr Hosp. 2010 Jul-Aug;25(4):630-4.
The aim of the present study was to explore the relationship of resistin levels with inflammatory markers and anthropometric parameters in morbid obese patients.
A population of 46 morbid obese was analyzed. A complete nutritional and biochemical evaluation was performed. Patients were divided in two groups by median resistin value (3.49 ng/ml), group I (low values, average value 2.60 +/- 0.5) and group II (high values, average value 5.71 +/- 2.25).
Patients in the group II had higher weight, BMI, fat mass, waist circumference, LDL-cholesterol, triglycerides, fibrinogen and C reactive protein than patients in group I. In the multivariate analysis with age- and sex-adjusted basal resistin concentration as a dependent variable, only fibrinogen and LDL cholesterol remained as an independent predictor in the model (F = 8.5; p < 0.05). Resistin concentration increase 0.01 ng/ml (CI 95%: 0.003-0.017) for each mg/dl of fibrinogen increased. Resistin concentration increase 0.03 ng/ml (CI 95%: 0.003-0.049) for each mg/dl of LDL-cholesterol increased.
Circulating resistin concentrations are associated with different inflammatory markers, triglycerides, LDL cholesterol and anthropometric variables in morbid obese patients. Further studies are needed to explore these interesting relationships.
本研究旨在探讨病态肥胖患者中抵抗素水平与炎症标志物及人体测量参数之间的关系。
分析了46例病态肥胖人群。进行了全面的营养和生化评估。根据抵抗素中位数（3.49 ng/ml）将患者分为两组，第一组（低值组，平均值2.60±0.5）和第二组（高值组，平均值5.71±2.25）。
第二组患者的体重、体重指数、脂肪量、腰围、低密度脂蛋白胆固醇、甘油三酯、纤维蛋白原和C反应蛋白均高于第一组患者。在以年龄和性别校正的基础抵抗素浓度作为因变量的多变量分析中，模型中仅纤维蛋白原和低密度脂蛋白胆固醇仍为独立预测因子（F = 8.5；p < 0.05）。纤维蛋白原每增加1 mg/dl，抵抗素浓度增加0.01 ng/ml（95%置信区间：0.003 - 0.017）。低密度脂蛋白胆固醇每增加1 mg/dl，抵抗素浓度增加0.03 ng/ml（95%置信区间：0.003 - 0.049）。
病态肥胖患者中循环抵抗素浓度与不同的炎症标志物、甘油三酯、低密度脂蛋白胆固醇及人体测量变量相关。需要进一步研究来探索这些有趣的关系。
Zotero 插件