Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
J Cereb Blood Flow Metab. 2010 Dec;30(12):1982-6. doi: 10.1038/jcbfm.2010.132. Epub 2010 Aug 11.
Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.
近年来,人们对神经元-星形胶质细胞相互作用的各个方面进行了大量的数学建模,脑能量代谢领域也不例外。尽管该领域出现了生物物理模型,但关于乳酸在脑能量代谢中的作用的长期争论仍未解决。恰恰相反,它已经被引入了微分方程的世界。在这里,我们从建模者的角度总结了目前的讨论状态,并提请非数学专业读者注意一些关键点。