镉与肌动蛋白微丝在体外的相互作用。

Interaction of cadmium with actin microfilaments in vitro.

作者信息

Díaz-Barriga F, Carrizales L, Yanez L, Hernández J M, Domínguez Robles M C, Palmer E, Saborío J L

机构信息

Lab. Biofarmacia y Toxicidad Celular, Departamento de Biología Celular, Facultad de Medicina, Universidad Autonoma de San Luis Postosí, Apartado Postal 142, San Luis Potosí, SLP Mexico.

出版信息

Toxicol In Vitro. 1989;3(4):277-84. doi: 10.1016/0887-2333(89)90034-9.

DOI:10.1016/0887-2333(89)90034-9

PMID:20702293

Abstract

Cadmium, an environmental and occupational health hazard, can substitute for calcium in the activation of calmodulin in several in vitro assays. It was shown that Cd(2+) can substitute for Ca(2+) in the induction of actin-based gelation in cytoplasmic extracts from rat liver; gelation induced by either Ca(2+) or Cd(2+) is inhibited by trifluoperazine, a well known calmodulin inhibitor; and in MDCK cells there is a Cd(2+)-induced redistribution of actin filaments with the loss of stress fibres and the appearance of actin bundles at the periphery of these cells.

摘要

镉是一种环境和职业健康危害物，在多项体外试验中，它能够在钙调蛋白的激活过程中替代钙。研究表明，在大鼠肝脏细胞质提取物中，Cd(2+) 可以替代Ca(2+) 诱导基于肌动蛋白的凝胶化；三氟拉嗪（一种著名的钙调蛋白抑制剂）可抑制由Ca(2+) 或Cd(2+) 诱导的凝胶化；在MDCK细胞中，Cd(2+) 会诱导肌动蛋白丝重新分布，应力纤维消失，且在这些细胞周边出现肌动蛋白束。