State Clinic St. Poelten, Department of Internal Medicine 2, St. Poelten, Austria.
Thromb Res. 2010 Oct;126(4):350-2. doi: 10.1016/j.thromres.2010.07.007. Epub 2010 Aug 14.
Conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in stabilization of the fibrin clot. Fibrinogen consists of three pairs of non-identical polypeptide chains, encoded by different genes (fibrinogen alpha [FGA], fibrinogen beta [FGB] and fibrinogen gamma [FGG]). A functional single nucleotide polymorphism (SNP) in the 3' untranslated region of the FGG gene (FGG 10034C>T, rs2066865) has been associated with deep venous thrombosis and myocardial infarction. Aim of the present study was to analyze the role of this polymorphism in peripheral arterial disease (PAD). The study was designed as case-control study including 891 patients with documented PAD and 777 control subjects. FGG genotypes were determined by exonuclease (TaqMan) assays. FGG genotype frequencies were not significantly different between PAD patients (CC: 57.3%, CT: 36.7%, TT: 5.8%) and control subjects (CC: 60.9%, CT: 33.5%, TT 5.6%; p=0.35). In a multivariate logistic regression analysis including age, sex, smoking, diabetes, arterial hypertension and hypercholesterolemia, the FGG 10034 T variant was not significantly associated with the presence of PAD (Odds ratio 1.07, 95% confidence interval 0.84 - 1.37; p = 0.60). The FGG 10034C>T polymorphism was furthermore not associated with age at onset of PAD. We conclude that the thrombophilic FGG 10034 T gene variant does not contribute to the genetic susceptibility to PAD.
纤维蛋白原转化为纤维蛋白在止血中起着至关重要的作用，并导致纤维蛋白凝块的稳定。纤维蛋白原由三对非同源的多肽链组成，由不同的基因编码（纤维蛋白原α[FGA]、纤维蛋白原β[FGB]和纤维蛋白原γ[FGG]）。FGG 基因 3'非翻译区（UTR）的一个功能性单核苷酸多态性（SNP）（FGG 10034C>T，rs2066865）与深静脉血栓形成和心肌梗死有关。本研究旨在分析该多态性在外周动脉疾病（PAD）中的作用。该研究设计为病例对照研究，包括 891 例有记录的 PAD 患者和 777 例对照。通过外切酶（TaqMan）检测法确定 FGG 基因型。PAD 患者（CC：57.3%，CT：36.7%，TT：5.8%）和对照组（CC：60.9%，CT：33.5%，TT：5.6%）的 FGG 基因型频率无显著差异（p=0.35）。在包括年龄、性别、吸烟、糖尿病、动脉高血压和高胆固醇血症的多变量逻辑回归分析中，FGG 10034 T 变体与 PAD 的存在无显著相关性（优势比 1.07，95%置信区间 0.84-1.37；p=0.60）。FGG 10034C>T 多态性与 PAD 的发病年龄也无相关性。我们得出结论，血栓形成倾向的 FGG 10034 T 基因变体不增加 PAD 的遗传易感性。
