Driver mutations: a roadmap for getting close and personal in pancreatic cancer.
作者信息
Korc Murray
机构信息
Departments of Medicine, and Pharmacology & Toxicology, and the Norris Cotton Cancer Center at Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH, USA.
出版信息
Cancer Biol Ther. 2010 Sep 15;10(6):588-91. doi: 10.4161/cbt.10.6.13128. Epub 2010 Sep 24.
Abstract
摘要
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本文引用的文献
1
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).利用癌症特异性高通量注释体细胞突变（CHASM）对胰腺癌中的驱动突变进行优先级排序。
Cancer Biol Ther. 2010 Sep 15;10(6):582-7. doi: 10.4161/cbt.10.6.12537. Epub 2010 Oct 1.
2
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.突变 RAS 通过 DYRK1B 依赖性自分泌到旁分泌的 Hedgehog 信号转导变化。
Nat Struct Mol Biol. 2010 Jun;17(6):718-25. doi: 10.1038/nsmb.1833. Epub 2010 May 30.
3
Primary cilia regulate Gli/Hedgehog activation in pancreas.初级纤毛调节胰腺中的Gli/刺猬信号通路激活。
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10109-14. doi: 10.1073/pnas.0909900107. Epub 2010 May 17.
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The primary cilium: a signalling centre during vertebrate development.初级纤毛：脊椎动物发育过程中的信号中心。
Nat Rev Genet. 2010 May;11(5):331-44. doi: 10.1038/nrg2774.
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Kinase signaling pathways as targets for intervention in pancreatic cancer.激酶信号通路作为干预胰腺癌的靶点。
Cancer Biol Ther. 2010 May 15;9(10):754-63. doi: 10.4161/cbt.9.10.11534.
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Targeting the PI3K signaling pathway in cancer.针对癌症中的 PI3K 信号通路。
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Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.极光激酶-A 使小 GTP 酶 RalA 磷酸化、激活并重新定位。
Mol Cell Biol. 2010 Jan;30(2):508-23. doi: 10.1128/MCB.00916-08. Epub 2009 Nov 9.
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9
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.在胰腺癌小鼠模型中，抑制刺猬信号通路可增强化疗药物的递送。
Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.
10
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.急性胰腺炎显著加速表达致癌性Kras的小鼠的胰腺癌进展。
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