Department of Human Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, The Medical School, Beech Hill Road, Sheffield, UK.
Clin Endocrinol (Oxf). 2011 Apr;74(4):411-8. doi: 10.1111/j.1365-2265.2010.03855.x.
Anyone who has been in an endocrine clinic will appreciate that associations exist between autoimmune thyroid disease (AITD) and other autoimmune disorders. However, the full extent of these associations is still not fully appreciated, and new associations are being uncovered which may shed new light on the pathogenic basis for these connections, and the underlying reasons for them are only now becoming understood. This review is based on the British Thyroid Association Pitt-Rivers Lecture 2010. The first section provides an update on studies which have detailed the strength of various autoimmune disease associations, the second section discusses the environmental and genetic factors which underlie these associations and the final section describes some recently identified, unexpected AITD associations. Unravelling these associations further will illuminate the pathogenesis of autoimmune diseases and offers the prospect of new therapeutic approaches.
任何曾在内分泌科工作过的人都会意识到自身免疫性甲状腺疾病（AITD）与其他自身免疫性疾病之间存在关联。然而，这些关联的全部程度仍未被充分认识，新的关联正在被发现，这可能为这些联系的发病基础以及它们背后的原因提供新的认识。这篇综述基于 2010 年英国甲状腺协会皮特-里弗斯讲座。第一节提供了详细研究的最新进展，这些研究详细说明了各种自身免疫性疾病关联的强度，第二节讨论了这些关联所基于的环境和遗传因素，最后一节描述了一些最近发现的、出乎意料的 AITD 关联。进一步阐明这些关联将阐明自身免疫性疾病的发病机制，并为新的治疗方法提供前景。
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