Kwak Jaechan, Workman Jerry L, Lee Daeyoup
Department of Biological Sciences, KAIST, Yuseong-Gu, Daejeon, 305-701, Korea.
Biochim Biophys Acta. 2011 Feb;1809(2):88-96. doi: 10.1016/j.bbagrm.2010.08.001. Epub 2010 Aug 17.
Cumulative evidence indicates that the proteasome, which is mainly known as a protein-degrading machine, is very essential for gene expression. Destructive functions of the proteasome, i.e., ubiquitin-dependent proteolytic activity, are significant for activator localization, activator destruction, co-activator/repressor destruction and PIC disassembly. Non-proteolytic functions of the proteasome are important for recruitment of activators and co-activators to promoters, ubiquitin-dependent histone modification, transcription elongation and possibly maturation of mRNA via the facilitation of mRNA export from the nucleus to the cytoplasm. In this review, we discuss how the proteasome regulates transcription at numerous stages during gene expression. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough!
越来越多的证据表明，蛋白酶体虽然主要作为一种蛋白质降解机器为人所知，但对基因表达非常重要。蛋白酶体的破坏性功能，即泛素依赖性蛋白水解活性，对于激活剂定位、激活剂破坏、共激活剂/阻遏物破坏以及预起始复合物解体具有重要意义。蛋白酶体的非蛋白水解功能对于激活剂和共激活剂募集到启动子、泛素依赖性组蛋白修饰、转录延伸以及可能通过促进mRNA从细胞核输出到细胞质来实现mRNA成熟很重要。在这篇综述中，我们讨论了蛋白酶体如何在基因表达的多个阶段调节转录。本文是名为“26S蛋白酶体：降解远远不够！”的特刊的一部分。
