人类免疫缺陷病毒1型反式激活因子蛋白介导的跨细胞反式激活
Transcellular transactivation by the human immunodeficiency virus type 1 tat protein.
作者信息
Helland D E, Welles J L, Caputo A, Haseltine W A
机构信息
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
出版信息
J Virol. 1991 Aug;65(8):4547-9. doi: 10.1128/JVI.65.8.4547-4549.1991.
Abstract
The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.
摘要
1型人类免疫缺陷病毒（HIV-1）反式激活因子（tat）蛋白在一个细胞中产生，可激活第二个细胞中HIV-1启动子指导的基因表达，前提是这些细胞彼此直接接触。这一观察结果表明，在HIV-1感染细胞中产生的tat蛋白对邻近细胞具有生理效应。
Zotero 插件