静止 T 细胞与 HIV：悬而未决的关系。
Quiescent T cells and HIV: an unresolved relationship.
机构信息
Department of Medicine, Division of Hematology/Oncology, UCLA AIDS Institute, David Geffen School of Medicine at UCLA, 615 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
出版信息
Immunol Res. 2010 Dec;48(1-3):110-21. doi: 10.1007/s12026-010-8171-0.
Abstract
The ability of HIV to infect quiescent CD4+ T cells has been a topic of intense debate. While early studies suggested that the virus could not infect this particular T cell subset, subsequent studies using more sensitive protocols demonstrated that these cells could inefficiently support HIV infection. Additional studies showed that the kinetics of infection in quiescent cells was delayed and multiple stages of the viral life cycle were marred by inefficiencies. Despite that, proviral DNA has been found in these cells presenting them as a potential viral reservoir. Therefore, a better understanding of the relationship between HIV and quiescent T cells may lead to further advances in the field of HIV.
摘要
HIV 感染静止 CD4+T 细胞的能力一直是激烈争论的话题。虽然早期的研究表明病毒不能感染这个特定的 T 细胞亚群，但随后使用更敏感方案的研究表明，这些细胞可以低效地支持 HIV 感染。其他研究表明，在静止细胞中的感染动力学被延迟，病毒生命周期的多个阶段都因效率低下而受到阻碍。尽管如此，在这些细胞中已经发现了前病毒 DNA，这使它们成为潜在的病毒储存库。因此，更好地了解 HIV 与静止 T 细胞之间的关系可能会推动 HIV 领域的进一步发展。
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