β3 肾上腺素能受体基因 Trp64Arg 多态性在运动员中的分布及其对心血管功能的影响。

Distribution of the Trp64Arg polymorphism in the ß 3-adrenergic receptor gene in athletes and its influence on cardiovascular function.

机构信息

College of Physical Education, Hanyang University, Seoul, Korea.

出版信息

Kardiol Pol. 2010 Aug;68(8):920-6.

PMID:20730725

Abstract

BACKGROUND

The Trp64Arg polymorphism in the beta₃-adrenergic receptor (beta₃-AR) gene was extensively studied concerning the relationship with cardiovascular (CV) diseases, but few studies addressed this issue in athletes.

AIM

To examine the relationship between the Trp64Arg polymorphism in the beta₃-AR gene and several CV functions such as cardiac structure and function or blood biochemical parameters in Korean male controls and athletes.

METHODS

We recruited a total of 114 study subjects, including 81 male athletes (8 long distance runners, 17 soccer, 8 baseball, 10 basketball, 8 volleyball, 8 ice hockey, 8 judo, 6 taekwondo and 8 gymnastics) and 33 controls. Two dimensional echocardiography was performed in order to assess the cardiac structure and function and blood biochemical parameters were measured. Genotyping of Trp64Arg polymorphism in the beta₃-AR gene was also performed by the SNaPshot method.

RESULTS

The genotype and allele distribution of Trp64Arg polymorphism in the beta₃-AR gene were significantly different among each sporting discipline, showing the highest Arg allele frequency in volleyball and gymnastics (p < 0.05). Also, this polymorphism was significantly associated with serum HDL-cholesterol and glucose level in athletes only (p < 0.05).

CONCLUSIONS

Our data showed the significant associations between the Trp64Arg polymorphism in the beta₃-AR gene and some CV parameters such as serum HDL-cholesterol and glucose levels in athletes. However, further studies of the precise mechanism behind these associations are needed.

摘要

背景

β₃-肾上腺素能受体（β₃-AR）基因中的 Trp64Arg 多态性与心血管（CV）疾病的关系已被广泛研究，但很少有研究涉及运动员。

目的

检查β₃-AR 基因中的 Trp64Arg 多态性与韩国男性对照组和运动员的几个 CV 功能之间的关系，如心脏结构和功能或血液生化参数。

方法

我们共招募了 114 名研究对象，包括 81 名男性运动员（8 名长跑运动员、17 名足球运动员、8 名棒球运动员、10 名篮球运动员、8 名排球运动员、8 名冰球运动员、8 名柔道运动员、6 名跆拳道运动员和 8 名体操运动员）和 33 名对照者。进行二维超声心动图检查以评估心脏结构和功能，并测量血液生化参数。通过 SNaPshot 法对 Trp64Arg 多态性进行基因分型。