Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
Am J Respir Crit Care Med. 2011 Jan 15;183(2):195-203. doi: 10.1164/rccm.201001-0115OC. Epub 2010 Aug 27.
An acute-care visit for asthma often signals a management failure. Although a written action plan is effective when combined with self-management education and regular medical review, its independent value remains controversial.
We examined the efficacy of providing a written action plan coupled with a prescription (WAP-P) to improve adherence to medications and other recommendations in a busy emergency department.
We randomized 219 children aged 1-17 years to receive WAP-P (n = 109) or unformatted prescription (UP) (n = 110). All received fluticasone and albuterol inhalers, fitted with dose counters, to use at the discretion of the emergency physician. The main outcome was adherence to fluticasone (use/prescribed × 100%) over 28 days. Secondary outcomes included pharmacy dispensation of oral corticosteroids, β(2)-agonist use, medical follow-up, asthma education, acute-care visits, and control.
Although both groups showed a similar drop in adherence in the initial 14 days, adherence to fluticasone was significantly higher over Days 15-28 in children receiving WAP-P (mean group difference, 16.13% [2.09, 29.91]). More WAP-P than UP patients filled their oral corticosteroid prescription (relative risk, 1.31 [1.07, 1.60]) and were well-controlled at 28 days (1.39 [1.04, 1.86]). Compared with UP, use of WAP-P increased physicians' prescription of maintenance fluticasone (2.47 [1.53, 3.99]) and recommendation for medical follow-up (1.87 [1.48, 2.35]), without group differences in other outcomes.
Provision of a written action plan significantly increased patient adherence to inhaled and oral corticosteroids and asthma control and physicians' recommendation for maintenance fluticasone and medical follow-up, supporting its independent value in the acute-care setting. Clinical trial registered with www.clinicaltrials.gov (NCT 00381355).
哮喘的急性护理就诊通常表明管理失败。虽然书面行动计划在与自我管理教育和定期医疗审查结合使用时是有效的,但它的独立价值仍存在争议。
我们研究了在繁忙的急诊室中提供书面行动计划(WAP-P)加处方(WAP-P)对改善药物和其他建议的依从性的效果。
我们将 219 名 1-17 岁的儿童随机分为 WAP-P 组(n=109)或未格式化处方(UP)组(n=110)。所有患者均接受氟替卡松和沙丁胺醇吸入器治疗,并配有剂量计数器,由急诊医生酌情使用。主要结局是在 28 天内使用氟替卡松(使用/处方×100%)的依从性。次要结局包括口腔皮质类固醇的药房配药、β(2)-激动剂的使用、医疗随访、哮喘教育、急性护理就诊和控制情况。
尽管两组在前 14 天内都表现出相似的依从性下降,但在接受 WAP-P 的儿童中,在第 15-28 天期间,使用氟替卡松的依从性明显更高(组间差异,16.13%[2.09,29.91])。接受 WAP-P 的患者比接受 UP 的患者更有可能开出口服皮质类固醇处方(相对风险,1.31[1.07,1.60]),并且在 28 天内得到很好的控制(1.39[1.04,1.86])。与 UP 相比,WAP-P 的使用增加了医生开维持性氟替卡松的处方(2.47[1.53,3.99])和建议进行医疗随访(1.87[1.48,2.35]),但其他结局两组之间无差异。
提供书面行动计划显著提高了患者对吸入和口服皮质类固醇的依从性以及哮喘的控制,并且增加了医生对维持性氟替卡松和医疗随访的建议,支持其在急性护理环境中的独立价值。该临床试验已在 www.clinicaltrials.gov 注册(NCT 00381355)。