从真菌 Chaetomium elatum ChE01 中分离得到的细胞毒性 10-(吲哚-3-基)-[13]细胞松弛素。
Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01.
机构信息
Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
出版信息
Arch Pharm Res. 2010 Aug;33(8):1135-41. doi: 10.1007/s12272-010-0801-5. Epub 2010 Aug 28.
Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin III(ed) (3); six known chaetoglobosins B-D (4-6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5alpha,8alpha-epidioxyergosta-6-22-diene-3beta-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1-9 showed cytotoxicity against the human breast cancer (IC(50) 2.54-21.29 microM) and cholangiocarcinoma cell lines (IC(50) 3.41-86.95 microM).
从真菌 Chaetomium elatum ChE01 中分离得到了 9 种 10-(吲哚-3-基)-[13]细胞松弛素，如一种新的 chaetoglobosin V (1)；两种新的天然产物，prochaetoglobosin III (2) 和 prochaetoglobosin III(ed) (3)；六种已知的 chaetoglobosins B-D (4-6)、F (7) 和 G (8) 以及 isochaetoglobosin D (9)，此外还有两种已知的甾醇，24(R)-5alpha,8alpha-epidioxyergosta-6-22-diene-3beta-ol (10) 和麦角固醇 (11)。这些化合物的结构通过光谱方法阐明。化合物 1-9 对人乳腺癌（IC(50) 2.54-21.29 microM）和胆管癌细胞系（IC(50) 3.41-86.95 microM）具有细胞毒性。
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