与单用福莫特罗相比，COPD 患者使用福莫特罗/布地奈德都保和福莫特罗/倍氯米松复方制剂能更快地舒张支气管。
Rapid onset of bronchodilation with formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler as compared to formoterol alone in patients with COPD.
机构信息
Unit of Respiratory Clinical Pharmacology, Department of Internal Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy.
出版信息
Pulm Pharmacol Ther. 2011 Feb;24(1):118-22. doi: 10.1016/j.pupt.2010.08.005. Epub 2010 Sep 8.
In the present study, we examined whether there is a difference in the onset of bronchodilatation between formoterol/beclomethasone 12/200 μg Modulite and formoterol/budesonide 9/320 μg Turbuhaler in patients with COPD. We enrolled 28 patients with stable COPD. Both formoterol/beclomethasone and formoterol/budesonide elicited a larger mean FEV₁-AUC₀₋₁₅min than formoterol alone, whereas there was no significant difference between their FEV₁-AUC₀₋₁₅min. Also the change in FEV₁ 15 min after inhalation of formoterol/beclomethasone combination or formoterol/budesonide combination was greater than that induced by formoterol alone. This study confirms the rapid effect of the inhaled corticosteroid component when combined with formoterol and indicates that the onset of bronchodilation of formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler are similar and greater than formoterol alone in patients with COPD.
在本研究中，我们考察了在 COPD 患者中，福莫特罗/丙酸倍氯米松 12/200μg Modulite 和福莫特罗/布地奈德 9/320μg Turbuhaler 的支气管扩张作用起始时间是否存在差异。我们纳入了 28 例稳定期 COPD 患者。福莫特罗/丙酸倍氯米松和福莫特罗/布地奈德均比福莫特罗单独使用产生更大的平均 FEV₁-AUC₀₋₁₅min，而它们的 FEV₁-AUC₀₋₁₅min 没有显著差异。吸入福莫特罗/丙酸倍氯米松联合用药或福莫特罗/布地奈德联合用药后 15 分钟时 FEV₁的变化也大于福莫特罗单独使用时的变化。本研究证实了吸入性皮质激素与福莫特罗联合使用时的快速作用，并表明在 COPD 患者中，福莫特罗/丙酸倍氯米松 Modulite 和福莫特罗/布地奈德 Turbuhaler 的支气管扩张作用起始时间与福莫特罗单独使用相似，且大于福莫特罗单独使用。
Zotero 插件